Ned Budisa is a pioneer in chemical synthetic biology. His works are targeting expansion of the limits of the genetic code, the universal genetic language of living beings on our planet. The ultimate goal of his mission is to create synthetic life forms, alien beings made by humans and living in a test tube. This will offer completely new understanding of what are the boundaries of life, and ideally help us to articulate the definition of life in terms of biochemical science. Notwithstanding the fundamental meaning of genetic code reprograming, the biotechnological opportunities opened by this endeavor are immense, as this opens a new avenue towards novel methods in biomedical disciplines and material science.