Applications

1. Biotechnology of the Synthetic Cells and Proteins:
   • Use of engineered organisms and proteins in materials science, medicine, and environmental sustainability.
   • Advances in cell-surface enzyme display and genomic integration for biotechnological innovation.
2. Biocatalysis with Non-canonical Amino Acids (ncAAs):
   • Development of novel enzymatic systems for industrial and environmental use.
   • Application of orthogonal enzymes in creating specialized chemical transformations.
3. Classical and Modern Protein Chemistry:
   • Fusion of classical peptide synthesis with advanced protein design.
   • Studies in folding, stability, and novel chemistries within engineered proteins.
4. Bioorthogonal Conjugations & Click Chemistry:
   • Labeling, tracking, and modifying biomolecules in research, diagnostics, and therapeutic applications.
   • Study biological processes in real time without causing unwanted side effects.
5. Protein and Cellular Biophysics with Site-specific Labeling:
   • Spectroscopic probes: Incorporated ncAAs can carry unique handles (e.g., nitrile groups) for specialized spectroscopic techniques such as IR, NMR, or fluorescence measurements.
   • Mapping local environments: ncAAs sensitive to electric fields or hydrogen bonds provide direct insight into microenvironments within proteins and membranes.

Further Reading: